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Tianeptine Sodium, also known as stablon, is a drug primarily used in the treatment of Major depressive disorder. It has also been used to treat irritable bowel syndrome and asthma. Tianeptine has antidepressant and anti-anxiety properties.
Tianeptine Sodium has a variety of effects on the body, including motivation enhancement, anxiety suppression, cognitive euphoria, focus enhancement, rejuvenation, and cognitive fatigue.
Tianeptine is antidepressant. The animal has the hippocampus pyramidal cells increased spontaneousactivity, and accelerating its function was inhibited after recovery; increase in cortical and hippocampalneurons at sites of5- serotonin reuptake. Tianeptine without following adverse effects: sleep and alertness;cardiovascular system; cholinergic system ( without anticholinergic symptoms ); drug craving
|Product Name||Tianeptine sodium salt powder|
|Chemical Name||Tianeptine sodium; Tianeptine sodium salt; 30123-17-2; Stablon; Coaxil;|
|Monoisotopic Mass||458.104 g/mol|
|Melting Point ||1800C|
|Boiling Point||609.2 °C at 760 mmHg|
|Color||White to off-white powder|
|Solubility ||DMSO: ≥20mg/mL|
|Storage Temperature ||Desiccate at RT|
|Application||Tianeptine sodium salt powder is a salt of Tianeptine.|
Tianeptine is antidepressant.
Tianeptine sodium salt powder (30123-17-2)
Tianeptine sodium salt is a salt of Tianeptine. Tianeptine, a tricyclic compound, is a selective facilitator of 5-HT (serotonin; sc-201146) uptake in vitro and in vivo. Additionally, Tianeptine is reported to act as a selective inhibitor of dopamine uptake and is similar to amineptine. Tianeptine does not have a noted effect on monoamine uptake. In a study utilizing purified synaptosomes from rat brain, Tianeptine was reported to enhance serotonin uptake in selective brain regions. Purified synaptosomes were obtained from rats and incubated with tritium-labeled 5-HT and Tianeptine in vitro . The synaptosomes were then analyzed for uptake and release of 5-HT via a liquid scintillation counter.
Raw Tianeptine sodium salt powder is an atypical antidepressant with diverse actions, most notably on the glutamatergic system.It attenuates glutamate release and modulates the function of the AMPA receptor.Tianeptine also acts as an agonist of the μ-opioid receptor (EC50s = 194 and 641 nM for human and mouse receptors, respectively). It is as effective as fluoxetine in the management of post-traumatic stress disorder.
Tianeptine sodium salt has nootropic abilities in regards to individuals whose cognition is negatively impacted by mood disorders and has the ability to improve focus and concentration in individuals who have poor attention spans as well.
Tianeptine sodium salt powder (30123-17-2) Mechanism of Action
Recent studies suggest that tianeptine acts as a full agonist at the mu-type opioid receptor (MOR). Tianeptine has challenged the monoaminergic hypothesis of depression, as well as the widely supported monoaminergic mechanisms whereby the action of most known antidepressants have been explained. Specifically, this drug is thought to persistently alter glutamate receptor bursting of the hippocampal CA3 commissural associational synapse. Current research suggests that tianeptine produces its antidepressant effects through the modulation of glutamate receptor activity (for example, AMPA receptors and NMDA receptors) and affect the release of brain-derived neurotrophic factor (BDNF), which impacts neural plasticity. More recent studies by support the role of tianeptine in the modulation of glutaminergic activity in the amygdala, the emotional region of the brain associated with memories.
Tianeptine reduces the hypothalamic-pituitary-adrenal response to stress, and thus prevents stress-related behavioral issues. In rodents, the stress of acute restraint increases extracellular levels of glutamate in the basolateral amygdala an effect that was inhibited by tianeptine. Interestingly, the SSRI fluoxetine increased extracellular glutamate levels in the basolateral amygdala regardless of stress conditions. These data demonstrate that the mechanism of action of tianeptine is distinct from SSRIs and support the hypothesis that the mechanism of action of tianeptine relates to alteration of glutaminergic activity in the amygdala and the hippocampus.
In addition to the above mechanisms, tianeptine is a unique antidepressant and anxiolytic medication that stimulates the uptake of serotonin (5-hydroxytryptamine; 5-HT), and 5-hydroxyindoleacetic acid (5-HIAA) in brain tissue.
Although the monoaminergic neurotransmitters serotonin (5-HT), noradrenaline (NA) and dopamine (DA) are proven to be related to the occurrence of depressive disorders, it is now recognized that monoamine deficits are not sufficient to explain the mechanism of action of antidepressant medications.
Benefits of Tianeptine sodium salt powder (30123-17-2)
Tianeptine sodium salt can treat major depressive disorder.
Tianeptine sodium salt has anti-anxiety and antidepressant and and nootropic qualities.
Tianeptine sodium salt enhance mood and improve mental status.
Tianeptine sodium salt could block panic attacks from occurring.
Tianeptine sodium salt treat pain associated with fibromyalgia.
Tianeptine sodium salt used in treatment of depression in men with dysfunction.
Tianeptine sodium salt has mild efficacy for ADHD.
Tianeptine sodium salt also promotes neuroplasticity.
Recommended Tianeptine sodium salt powder (30123-17-2) Dosage
Tianeptine Sodium has a short half-life at only about 2.5 hours14, and requires two redoses throughout the day. The tianeptine sodium dosage is 12.5 mg taken three times daily, for a total of 37.5mg per day.
Do not exceed 50mg of Tianeptine Sodium in one day. Doing so can open the door for further abuse and addiction potential.
Side effects of Tianeptine sodium salt powder (30123-17-2)
Tianeptine sodium salt powder interacts with many parts of the brain including the opiod receptors, which can create the side effect of euphoria. Other side effects with varying frequency include the following:
▲ Headache (up to 18%)
▲ Dizziness (up to 10%)
▲ Insomnia / night terrors (up to 20%)
▲ Drowsiness (up to 10%)
▲ Dry mouth (up to 20%)
Other side effects include things like constipation, nausea, anxiety or Liver Toxicity. More severe concerns include withdrawal after abuse and an estimated 0.1 – 0.3% of users will have this problem. How ever, as you can see, the side effects of Tianeptine sodium salt are going to depend on the individual and personal biochemistry.
It is worth noting that:
Older patients should take a smaller dosage of Tianeptine sodium salt, as should patients with renal failure. Dosage does not need to be adjusted in patients with alcoholism or hepatic impairment, or patients on dialysis .While Antidepressants, like tianeptine, increased the risk of liver toxicity.
Tianeptine is a drug used primarily in the treatment of major depressive disorder, although it may also be used to treat asthma or irritable bowel syndrome. Chemically it is a tricyclic antidepressant (TCA), but it has different pharmacological properties than typical TCAs as recent research suggests that tianeptine produces its antidepressant effects through indirect alteration of glutamate receptor activity (i.e., AMPA receptors and NMDA receptors) and release of BDNF, in turn affecting neural plasticity.
Tianeptine Sodium Keep You Away from Depression
Tianeptine has antidepressant and anxiolytic (anti-anxiety) properties with a relative lack of sedative, anticholinergic and cardiovascular adverse effects, thus suggesting it is particularly suitable for use in the elderly and in those following alcohol withdrawal; such persons can be more sensitive to the adverse effects of psychotropic drugs. Recent results indicate possible anticonvulsant (anti-seizure) and analgesic (painkilling) activity of tianeptine via immediate or downstream modulation of adenosine A1 receptors (as the effects could be experimentally blocked by antagonists of this receptor).